Herbalbase is a novel database where the efficacy and safety of natural medicines is evaluated by evidence-based medicine techniques. It is important to note that the assessment of efficacy and safety in Herbalbase has been made in general, not product, level. Different preparations may contain various amounts of active ingredients e.g. depending on the timing of collection of such plant or differences in the production process. In Herbalbase, the indications of natural medicines are divided into evidence-based use if the documentation is based on a sufficiently large randomized controlled clinical trials, and traditional use in case the use relies on a well-established base, but the clinical evidence of efficacy is incomplete.